Figure 1. Wiz haploinsufficiency increases silencing at the A^vy locus.

Pedigree charts (left) are shown for generating F1 mice heterozygous for the A^vy allele and either wildtype or heterozygous for Wiz^MommeD30. Wiz^MommeD30/+ mice were crossed to pseudoagouti A^vy/a mice, numbers of F1 mice in each cohort are indicated. The proportions of coat colours for F1 mice are shown (right) from a cross with either a Wiz^MommeD30/+ sire (A) or dam (B). Chi-squared tests were carried out to determine significance, *p-value<0.05, **p-value<0.005.

DOI: http://dx.doi.org/10.7554/eLife.15082.002