Figure 7. Wiz^MommeD30/+ mice show decreased activity and increased anxiety-like behaviour.

(A) Line graph illustrating the average 24 hr activity profile from Wiz^+/+ and Wiz^MommeD30/+ mice, collapsed from 12 days of testing. The pattern of activity is broadly similar between the genotypes, though Wiz^MommeD30/+ mice show decreased activity in the first two hours and the fifth hour of the active phase of the light/dark cycle. Grey box indicates the dark phase of the light/dark cycle. (B) Bar graph showing decreased open arm entries among Wiz^MommeD30/+ mice compared with Wiz^+/+ mice, after 5 min intervals on the EPM test. (C) Heat map of locomotor activity on the EPM from a representative Wiz^+/+ mouse (top) and a representative Wiz^MommeD30/+ mouse (bottom). Broken lines indicate the location of the closed arms of the EPM. (D) Percentage of time Wiz^+/+ (n = 21) and Wiz^MommeD30/+ (n = 22) mice spent in the light portion of a light-dark test. (E) The number of vertical counts (rearing) Wiz^+/+ and Wiz^MommeD30/+ mice showed in the light-dark test. Error bars represent ± SEM, *p-value <0.05, **p-value 0.005, ***p-value <0.0005.

DOI: http://dx.doi.org/10.7554/eLife.15082.012

Figure 7—figure supplement 1. No difference in temperature in Wiz^MommeD30/+ mice.

Telemetry data from across 3 days were collapsed into hourly intervals and the average temperature of Wiz^+/+ (black data points) and Wiz^MommeD30/+ (red data points) mice is shown. Lights on is indicated by light background and lights off is indicated by grey background. Numbers of mice for each cohort are indicated. Error bars are the SEM.

DOI: http://dx.doi.org/10.7554/eLife.15082.013