Table 1. Baseline Characteristics.
| Overall(n=151) | 3TC group (n=60) | TDF group (n=91) | P value (3TC vs. TDF) | |
|---|---|---|---|---|
| Male sex (n, %) | 125 (82.8) | 47 (78.3) | 78 (85.7) | 0.24 |
| Age (years, IQR) | 36 (30,45) | 34 (30, 41) | 37 (30, 47) | 0.16 |
| Route of transmission (n, %) | 0.29a | |||
| MSM | 44 (29.1) | 21 (35.0) | 23 (25.3) | |
| Heterosexual | 94 (62.3) | 33 (55.0) | 61 (67.0) | |
| Blood | 1 (0.7) | 1 (1.7) | 0 (0.0) | |
| Others/Unknown | 12 (7.9) | 5 (8.3) | 7 (7.7) | |
| CD4 cell count (cells/μl, IQR) | 200 (122, 307) | 150 (84, 241) | 229 (146, 332) | <0.001 |
| HIV RNA (log copies/ml, IQR) | 4.69 (4.22, 5.14) | 4.51 (4.08, 5.12) | 4.70 (4.37, 5.16) | 0.10 |
| HBV DNA (log IU/ml, IQR) | 3.59 (2.07, 7.52) | 3.69 (2.05, 8.04) | 3.49 (2.07, 6.53) | 0.39 |
| HBV DNA<20 IU/ml (n, %) | 23 (15.2) | 10 (16.7) | 13 (14.3) | 0.69 |
| HBV DNA>20000IU/ml (n, %) | 69 (45.7) | 29 (48.3) | 40 (44.0) | 0.60 |
| HBeAg positive (n, %) | 39 (25.8) | 18 (30.0) | 21 (23.1) | 0.34 |
| ALT (IU/l, IQR) | 29 (20, 43) | 28 (21, 44) | 30 (19, 43) | 0.98 |
| ALT>40IU/l (n, %) | 43 (28.5) | 17 (28.3) | 26 (28.6) | 0.98 |
| AST (IU/l, IQR)b | 28 (23, 39) | 28 (23, 40) | 29 (23, 34) | 0.68 |
| HBsAg quantification (log IU/ml, IQR) | 3.49 (2.76, 4.13) | 3.62 (2.77, 4.55) | 3.41 (2.70, 3.99) | 0.17 |
3TC, lamivudine; TDF tenofovir; MSM, men who have sex with men; IQR, interquartile ranges; HBeAg, HBV e antigen; ALT, alanine aminotransferase; AST, aspartate aminotransferase; IU, international unit; PEIU, Paul-Ehrlich-Institut unit.
a
using Fisher Exact test.
b
110 patients had AST data available.