Table 3.
mTBI regulated molecular pathways identified in hippocampal tissues 14 days after injury
| Up-regulated Z-score | |
|---|---|
| Pathway | Z-score |
| RIBOSOMAL PROTEINS | 6.01 |
| ELECTRON TRANSPORT CHAIN | 5.45 |
| TARTE MATURE PC | 5.27 |
| MOOTHA VOXPHOS | 4.92 |
| INNEREAR UP | 4.26 |
| ZUCCHI EPITHELIAL DN | 4.14 |
| UVB NHEK1 UP | 3.84 |
| IFN BETA GLIOMA DN | 3.83 |
| FALT BCLL UP | 3.78 |
| REOVIRUS HEK293 DN | 3.62 |
| DAC PANC UP | 3.50 |
| WALLACE JAK2 DIFF | 3.43 |
| OXIDATIVE PHOSPHORYLATION | 3.41 |
| SANSOM APC 5 DN | 3.39 |
| HIPPOCAMPUS DEVELOPMENT POSTNATAL | 3.30 |
| MOREAUX TACI HI VS LOW UP | 3.29 |
| REFRACTORY GASTRIC UP | 3.28 |
| CIS RESIST LUNG DN | 3.28 |
| PROSTAGLANDIN AND LEUKOTRIENE METABOLISM | 3.27 |
| UVB NHEK2 UP | 3.09 |
| BCNU GLIOMA MGMT 48HRS DN | 3.05 |
| UVB NHEK1 C4 | 2.92 |
| SHEPARD GENES COMMON BW CB MO | 2.91 |
| STRESS IONIZING SPECIFIC UP | 2.91 |
| UCALPAINPATHWAY | 2.91 |
| ALZHEIMERS DISEASE UP | 2.90 |
| NOS1 PATHWAY | 2.88 |
| NADLER OBESITY UP | 2.85 |
| ATRIA UP | 2.84 |
| INOS ALL DN | 2.84 |
| ICHIBA GVHD | 2.83 |
| BREAST CANCER ESTROGEN SIGNALING | 2.76 |
| BCNU GLIOMA NOMGMT 48HRS DN | 2.74 |
| GUO HEX DN | 2.73 |
| AKAP CENTROSOME PATHWAY | 2.72 |
| AGUIRRE PANCREAS CHR19 | 2.68 |
| HPV31 DN | 2.62 |
| IL6 FIBRO UP | 2.54 |
| FETAL LIVER VS ADULT LIVER GNF2 | 2.50 |
| TGF BETA C4 UP | 2.46 |
| KLEIN PEL DN | 2.44 |
| UBIQUINONE BIOSYNTHESIS | 2.40 |
| MPR PATHWAY | 2.37 |
| INFLAMMATION PATHWAY | 2.36 |
| ST GAQ PATHWAY | 2.34 |
| CHESLER BRAIN NEURAL HIGH GENES | 2.34 |
| LIAN MYELOID DIFF TF | 2.32 |
| ST MYOCYTE AD PATHWAY | 2.29 |
| UVC TTD 4HR UP | 2.28 |
| ABRAHAM MM VS AL DN | 2.27 |
| BCRABL HL60 AFFY DN | 2.26 |
| FERRANDO TAL1 NEIGHBORS | 2.24 |
| PASSERINI OXIDATION | 2.22 |
| SIG BCR SIGNALING PATHWAY | 2.18 |
| HEART FAILURE ATRIA UP | 2.17 |
| BLOOD CLOTTING CASCADE | 2.16 |
| MOREAUX TACI XG 13 DN | 2.15 |
| HANSON NFKAPPB IND | 2.14 |
| ABRAHAM AL VS MM UP | 2.13 |
| PGC1A PATHWAY | 2.13 |
| WNT PATHWAY | 2.10 |
| SARCOMAS SCHWANNOMA UP | 2.09 |
| POD1 KO UP | 2.08 |
| MITOCHONDRIA | 2.06 |
| LAL KO 6MO UP | 2.06 |
| CSK PATHWAY | 2.05 |
| AMI PATHWAY | 2.05 |
| XU CBP DN | 2.05 |
| MTA3 PATHWAY | 2.01 |
| BRENTANI HORMONAL FUNCTION | 2.01 |
| ROS MOUSE AORTA UP | 1.98 |
| GALE FLT3ANDAPL DN | 1.94 |
| CK1 PATHWAY | 1.90 |
| UVB NHEK4 24HRS DN | 1.84 |
| YANG OSTECLASTS SIG | 1.79 |
| BRENTANI IMMUNE FUNCTION | 1.72 |
| AKAP13 PATHWAY | 1.70 |
| ADIPOCYTE PPARG UP | 1.68 |
| YAO P4 KO VS WT DN | 1.64 |
| CROONQUIST IL6 RAS DN | 1.64 |
| TPA SKIN DN | 1.63 |
| Down-regulated Z-score | |
| Pathway | Z-score |
| CHEOK HDMTX DN | -1.62 |
| SARS PATHWAY | -1.72 |
| CELL CYCLE CHECKPOINT | -1.80 |
| MMS HUMAN LYMPH LOW 4HRS DN | -1.84 |
| HDACI COLON BUT30MIN DN | -2.01 |
| AGEING LYMPH DN | -2.05 |
| MANALO HYPOXIA DN | -2.06 |
| ROME INSULIN 2F UP | -2.07 |
| ALZHEIMERS INCIPIENT DN | -2.10 |
| HUMAN TISSUE TESTIS | -2.18 |
| OLD WERNER FIBRO UP | -2.22 |
| BOQUEST CD31PLUS VS CD31MINUS UP | -2.26 |
| NI2 MOUSE UP | -2.28 |
| UVB SCC UP | -2.30 |
| STOSSI ER UP | -2.37 |
| UVC HIGH D3 DN | -2.46 |
| UVC TTD-XPCS COMMON DN | -2.56 |
| IGF VS PDGF DN | -2.59 |
| CROMER HYPOPHARYNGEAL MET VS NON UP | -2.60 |
| UVB NHEK3 ALL | -2.64 |
| GH GHRHR KO 24HRS UP | -2.66 |
| UVC TTD ALL DN | -2.79 |
| UVB NHEK3 C5 | -2.81 |
| VALINE LEUCINE AND ISOLEUCINE BIOSYNTHESIS | -2.82 |
| CHEN HOXA5 TARGETS UP | -2.87 |
| DIAB NEPH DN | -2.88 |
| BLEO MOUSE LYMPH LOW 24HRS DN | -2.92 |
| UVB NHEK2 DN | -3.01 |
| YAGI AML PROG FAB | -3.06 |
| BRCA BRCA1 POS | -3.08 |
| ET743 SARCOMA 24HRS DN | -3.11 |
| VHL NORMAL UP | -3.11 |
| SANA TNFA ENDOTHELIAL DN | -3.12 |
| CHOLESTEROL BIOSYNTHESIS | -3.16 |
| IDX TSA DN CLUSTER6 | -3.31 |
| LEE T CELLS1 UP | -3.34 |
| LEE T CELLS10 UP | -3.34 |
| LEE T CELLS8 UP | -3.34 |
| ZHAN MM CD1 VS CD2 UP | -3.34 |
| CMV HCMV TIMECOURSE 24HRS DN | -3.35 |
| UVC TTD 4HR DN | -3.35 |
| BRCA1KO MEF DN | -3.42 |
| REOVIRUS HEK293 UP | -3.45 |
| TARTE PLASMA BLASTIC | -3.49 |
| HSC LATEPROGENITORS SHARED | -3.63 |
| HSC LATEPROGENITORS ADULT | -3.64 |
| HSC LATEPROGENITORS FETAL | -3.72 |
| BRCA PROGNOSIS NEG | -3.73 |
| UVC HIGH ALL DN | -3.81 |
| RCC NL UP | -3.82 |
| ET743 SARCOMA 72HRS DN | -3.85 |
| STEMCELL COMMON UP | -3.89 |
| LEE T CELLS2 UP | -3.95 |
| GH GHRHR KO 24HRS DN | -4.03 |
| KREBS TCA CYCLE | -4.13 |
| UVC XPCS 4HR DN | -4.16 |
| FLECHNER KIDNEY TRANSPLANT REJECTION DN | -4.16 |
| ET743 SARCOMA 48HRS DN | -4.16 |
| UVC XPCS 8HR DN | -4.48 |
| ET743 SARCOMA DN | -4.97 |
| ALZHEIMERS DISEASE DN | -5.25 |
| UVC XPCS ALL DN | -5.40 |
| POD1 KO DN | -5.90 |
| FLECHNER KIDNEY TRANSPLANT WELL UP | -6.68 |
| STEMCELL EMBRYONIC UP | -10.99 |
| STEMCELL NEURAL UP | -11.37 |