Fig. 5.
Drug loading and characterization of ultra-small hybrid nanoparticles. (a) Drug loading quantification of hybrid nanoparticles fabricated at increasing docetaxel input to PLGA weight ratios (n = 3; mean ± SD). (b) Cumulative release profile of docetaxel-loaded ultra-small hybrid nanoparticles with 2 wt% docetaxel loading over the course of 72 hours in 1X PBS (n = 3; mean ± SD). (c) Cell viability of KB cells treated with either docetaxel-loaded ultra-small hybrid nanoparticles or Taxotere for 72 hours (n = 3; mean ± SD). Samples were normalized according to lysed cell and untreated controls.