Table 3.

Cox regression on mortality stratified by age

	Univariate		p	Multivariate		p
	HR	95 % CI	p	HR	95 % CI	p
Septic source
Abdominal versus respiratory	1.56	0.93–2.63	0.09	0.99	0.25–3.97	0.99
Abdominal versus urinary	0.47	0.14–1.61	0.23	0.86	0.04–16.75	0.92
Cardiovascular SOFA at t ₀	1.17	0.98–1.41	0.09	1.61	0.98–2.67	0.06
Coagulation SOFA at t ₀	1.10	0.95–1.28	0.21	0.96	0.68–1.36	0.83
Respiratory SOFA at t ₀	1.14	0.94–1.39	0.17	1.42	0.83–2.44	0.20
Renal SOFA at t ₀	0.97	0.81–1.17	0.75	0.85	0.53–1.38	0.52
Liver SOFA at t ₀	1.17	0.98–1.39	0.08	1.38	0.89–2.14	0.15
Δ Cardiovascular SOFA	1.39	1.20–1.62	<0.001	1.68	1.21–2.32	0.002
Δ Coagulation SOFA	1.46	1.13–1.90	0.004	1.64	1.07–2.50	0.022
Δ Respiratory SOFA	1.26	1.01–1.56	0.04	1.68	0.99–2.84	0.05
Δ Renal SOFA	1.29	0.94–1.76	0.11	0.83	0.47–1.47	0.51
Δ Liver SOFA	1.74	1.20–2.52	0.003	1.66	0.93–2.94	0.08
Timing^a	0.99	0.96–1.02	0.61	0.95	0.88–1.01	0.20
European versus asiatic	0.53	0.33–0.86	0.001	2.51	0.29–22.03	0.41

Italics indicates significant p values

^aTime between the diagnosis of severe sepsis/septic shock and PMX-HP