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. 2016 Aug 9;10:191. doi: 10.3389/fncel.2016.00191

Figure 2.

Figure 2

Effect of perinatal glufosinate ammonium exposure on neuroblast migration along the SVZ. (A) Diagram of a coronal section at SVZ level (green area). Coronal sections (red square) were stained with DCX (doublecortin; nearly exclusive expression in neuroblasts; green staining) and counterstained with DAPI (nuclear blue staining). Three measurements of thickness were carried for each SVZ (2 SVZ for each coronal section). Three coronal sections were analyzed per animal (Bregma 1.145; 0.745; 0.245); the mean of all values represents one mice. (B) The SVZ thickness of GLA0.2 exposed mice (n = 5) was significantly increased compared to CTL mice (n = 5). No difference was found in GLA1 exposed mice (n = 6). (C) Sections from GLA0.2 mice at PND15 display a more extensive SVZ thickness than CTL. SVZ thickness from GLA1 mice was similar to CTL but with ectopic migration of neuroblasts outside the SVZ (red arrows). Scale bar 100 μm. Each value represents the mean ± SEM (***p < 0.001). lv, lateral ventricle; Cpu, Caudate putamen.