| 1 Headache frequency |
4 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.1 After treatment |
4 |
2199 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.56 [‐0.65, ‐0.48] |
| 1.2 Follow‐up |
1 |
284 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.36 [‐0.59, ‐0.12] |
| 2 Response (at least 50% frequency reduction) |
4 |
|
Risk Ratio (IV, Fixed, 95% CI) |
Subtotals only |
| 2.1 After treatment |
4 |
2519 |
Risk Ratio (IV, Fixed, 95% CI) |
2.40 [2.08, 2.76] |
| 2.2 Follow‐up |
1 |
377 |
Risk Ratio (IV, Fixed, 95% CI) |
2.16 [1.35, 3.45] |
| 3 Headache frequency (various measures) |
4 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 3.1 Up to 8 weeks/2 months after randomization |
1 |
197 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.53 [‐0.83, ‐0.23] |
| 3.2 3 to 4 months after randomization |
4 |
2199 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.56 [‐0.65, ‐0.48] |
| 3.3 5 to 6 months after randomization |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 3.4 > 6 months after randomization |
1 |
284 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.36 [‐0.59, ‐0.12] |
| 4 Response |
4 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 4.1 Up to 8 weeks/2 months after randomization |
1 |
221 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.01 [1.32, 3.07] |
| 4.2 3 to 4 months after randomization |
4 |
2519 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.41 [2.10, 2.78] |
| 4.3 5 to 6 months after randomization |
0 |
0 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 4.4 > 6 months after randomization |
1 |
377 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.16 [1.35, 3.45] |
| 5 Migraine attacks |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 5.1 Up to 8 weeks/2 months after randomization |
1 |
197 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.70 [‐1.07, ‐0.33] |
| 5.2 3 to 4 months after randomization |
2 |
219 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.79 [‐1.12, ‐0.47] |
| 5.3 5 to 6 months after randomization |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 5.4 > 6 months after randomization |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 6 Migraine days |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 6.1 Up to 8 weeks/2 months after randomization |
1 |
198 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.50 [‐2.31, ‐0.69] |
| 6.2 3 to 4 months after randomization |
2 |
220 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.75 [‐2.43, ‐1.07] |
| 6.3 5 to 6 months after randomization |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 6.4 > 6 months after randomization |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 7 Headache days |
3 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 7.1 Up to 8 weeks/2 months after randomization |
1 |
198 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.90 [‐2.13, 0.33] |
| 7.2 3 to 4 months after randomization |
3 |
2177 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.17 [‐2.50, ‐1.83] |
| 7.3 5 to 6 months after randomization |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 7.4 > 6 months after randomization |
1 |
284 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.86 [‐3.08, ‐0.65] |
| 8 Headache intensity |
2 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 8.1 Up to 8 weeks/2 months after randomization |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 8.2 3 to 4 months after randomization |
2 |
1652 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.75 [‐0.85, ‐0.65] |
| 8.3 5 to 6 months after randomization |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 8.4 > 6 months after randomization |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 9 Analgesic use |
4 |
|
Std. Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 9.1 Up to 8 weeks/2 months after randomization |
1 |
198 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.29 [‐0.59, 0.01] |
| 9.2 3 to 4 months after randomization |
4 |
581 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.52 [‐1.22, 0.18] |
| 9.3 5 to 6 months after randomization |
1 |
50 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.25 [‐0.82, 0.33] |
| 9.4 > 6 months after randomization |
1 |
301 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.02 [‐0.24, 0.21] |
| 10 Headache scores |
3 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 10.1 Up to 8 weeks/2 months after randomization |
1 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 10.2 3 to 4 months after randomization |
3 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 10.3 5 to 6 months after randomization |
1 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 10.4 > 6 months after randomization |
1 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 11 Safety/acceptability |
4 |
|
Odds Ratio (IV, Fixed, 95% CI) |
Subtotals only |
| 11.1 Number of participants dropping out due to adverse effects |
2 |
260 |
Odds Ratio (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 11.2 Number of participants not reaching primary endpoint |
4 |
741 |
Odds Ratio (IV, Fixed, 95% CI) |
0.69 [0.46, 1.05] |
| 11.3 Number of participants with serious adverse events |
1 |
221 |
Odds Ratio (IV, Fixed, 95% CI) |
1.05 [0.19, 5.86] |
