Table 2.
Hematological values of male and female rats treated with 250, 500, and 1000 mg/kg of L. tigris E sclerotial powder for 28-days.
| Parameter | Treatment | |||
|---|---|---|---|---|
| Control | 1000 mg/kg | 500 mg/kg | 250 mg/kg | |
| MALE | ||||
| RBC (X 1012/L) | 7.50 ± 0.46 | 7.56 ± 0.11 | 8.00 ± 0.22 | 8.54 ± 0.77 |
| Hemoglobin (G/DL) | 15.98 ± 0.75 | 15.64 ± 0.49 | 15.98 ± 0.30 | 16.2 ± 1.15 |
| PCV (%) | 48.00 ± 2.65 | 47.60 ± 0.55 | 49.40 ± 0.55 | 48.80 ± 2.68 |
| MCV (FL) | 64.20 ± 2.17 | 62.60 ± 0.89 | 61.40 ± 1.95** | 57.20 ± 1.48** |
| MCH (PG) | 21.20 ± 0.84 | 20.60 ± 0.89 | 20.00 ± 0.71 | 19.00 ± 0.00** |
| MCHC (G/DL) | 33.20 ± 1.79 | 33.00 ± 1.41 | 32.40 ± 0.55 | 33.20 ± 0.45 |
| Platelet count (X 109/L) | 827.40 ± 138.51 | 935.40 ± 163.05 | 981.80 ± 100.36 | 926.80 ± 93.71 |
| WBC (X 109/L) | 9.38 ± 2.01 | 11.14 ± 2.78 | 10.48 ± 1.71 | 10.48 ± 1.47 |
| Neutrophil (%) | 47.40 ± 12.16 | 32.00 ± 15.52 | 19.40 ± 3.65** | 26.20 ± 7.09 |
| Lymphocyte (%) | 44.60 ± 17.34 | 62.80 ± 18.7 | 76.20 ± 4.32 | 68.40 ± 6.73 |
| Monocyte (%) | 7.80 ± 5.72 | 5.00 ± 4.12 | 4.40 ± 1.52 | 5.20 ± 2.17 |
| Eosinophil (%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Basophil (%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Atypical lymphocyte (%) | 0.20 ± 0.45 | 0.20 ± 0.45 | 0.00 ± 0.00 | 0.20 ± 0.45 |
| FEMALE | ||||
| RBC (X 1012/L) | 6.44 ± 0.54 | 7.12 ± 0.28 | 7.80 ± 0.42** | 8.40 ± 0.48** |
| Hemoglobin (G/DL) | 13.44 ± 1.11 | 14.94 ± 0.45** | 14.70 ± 0.69 | 16.30 ± 0.71** |
| PCV (%) | 39.20 ± 2.39 | 43.60 ± 1.14** | 46.00 ± 2.35** | 50.00 ± 1.58** |
| MCV (FL) | 61.40 ± 1.67 | 61.20 ± 1.10 | 59.20 ± 1.92 | 59.80 ± 1.92 |
| MCH (PG) | 21.00 ± 0.00 | 21.20 ± 0.45 | 19.00 ± 0.71** | 19.60 ± 0.55** |
| MCHC (G/DL) | 34.20 ± 1.10 | 34.20 ± 0.45 | 31.80 ± 0.45** | 32.60 ± 0.55** |
| Platelet count (X 109/L) | 798.40 ± 83.94 | 763.80 ± 114.88 | 956.80 ± 212.12 | 1001.80 ± 25.68** |
| WBC (X 109/L) | 5.46 ± 1.96 | 7.44 ± 0.68 | 7.82 ± 3.26 | 9.82 ± 1.70** |
| Neutrophil (%) | 18.40 ± 7.89 | 9.80 ± 2.86 | 11.00 ± 3.46 | 15.20 ± 8.64 |
| Lymphocyte (%) | 75.60 ± 6.58 | 85.80 ± 3.96** | 84.00 ± 3.81 | 79.60 ± 7.09 |
| Monocyte (%) | 6.00 ± 2.12 | 4.40 ± 1.14 | 4.60 ± 2.70 | 5.20 ± 4.21 |
| Eosinophil (%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.40 ± 0.89 | 0.00 ± 0.00 |
| Basophil (%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Atypical lymphocyte (%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
Values are expressed in mean ± SD (n = 5/group).
**
Significant difference with control (ANOVA, Dunnett's t (two-sided) test, p < 0.05).