Table 3.

Serum biochemical values of male and female rats treated with 250, 500, and 1000 mg/kg of L. tigris E sclerotial powder for 28-days.

Parameter	Treatment
	Control	1000 mg/kg	500 mg/kg	250 mg/kg
MALE
Glucose (mmol/L)	6.00 ± 0.77	6.00 ± 1.08	6.24 ± 0.68	6.66 ± 1.63
Urea (mmol/L)	6.44 ± 0.93	6.58 ± 0.98	5.38 ± 1.17	4.94 ± 0.21**
Creatinine (μmol/L)	15.20 ± 2.86	15.40 ± 3.65	12.00 ± 3.39	16.60 ± 4.04
Calcium (mmol/L)	2.52 ± 0.10	2.50 ± 0.05	2.37 ± 0.09**	2.49 ± 0.08
Inorganic phosphate (mmol/L)	3.75 ± 0.21	3.26 ± 0.35	3.11 ± 0.36**	3.17 ± 0.50
Uric acid (mmol/L)	0.11 ± 0.07	0.09 ± 0.02	0.07 ± 0.05	0.08 ± 0.06
Sodium (mmol/L)	145.80 ± 1.48	145.60 ± 1.14	146.20 ± 1.92	146.00 ± 2.00
Potassium (mmol/L)	4.48 ± 0.36	4.28 ± 0.38	4.84 ± 1.04	5.24 ± 1.00
Chloride (mmol/L)	107.00 ± 1.87	106.00 ± 0.71	109.20 ± 2.59	109.80 ± 1.48
Total cholesterol (mmol/L)	2.32 ± 0.47	2.10 ± 0.33	1.40 ± 0.16**	1.00 ± 0.48**
Total protein (G/L)	57.80 ± 2.59	58.20 ± 3.70	44.68 ± 22.08	54.60 ± 3.05
Albumin (G/L)	36.60 ± 1.95	37.20 ± 1.92	34.40 ± 1.52	34.60 ± 1.82
Globulin (G/L)	21.20 ± 0.84	21.00 ± 2.00	20.00 ± 1.00	20.00 ± 1.41
Total bilirubin (μmol/L)	1.80 ± 0.45	2.00 ± 0.00	2.00 ± 0.00	2.00 ± 0.00
Alkaline phosphatase (IU/L)	196.40 ± 42.44	169.20 ± 31.14	215.80 ± 20.85	177.00 ± 20.20
SGOT (AST) (IU/L)	239.00 ± 46.48	254.60 ± 24.63	252.00 ± 32.83	244.00 ± 43.00
SGPT (ALT) (IU/L)	61.20 ± 7.50	59.20 ± 5.22	65.60 ± 8.26	67.40 ± 8.44
GGT (IU/L)	1.80 ± 1.30	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
FEMALE
Glucose (mmol/L)	6.08 ± 0.37	6.48 ± 0.99	6.60 ± 0.51	7.28 ± 0.70
Urea (mmol/L)	7.48 ± 1.28	8.66 ± 1.24	7.08 ± 0.26	7.86 ± 0.72
Creatinine (μmol/L)	16.60 ± 5.13	18.00 ± 1.87	23.80 ± 4.15	23.60 ± 6.35
Calcium (mmol/L)	2.43 ± 0.05	2.36 ± 0.06	2.52 ± 0.07	2.66 ± 0.11**
Inorganic phosphate (mmol/L)	2.83 ± 0.28	2.75 ± 0.27	3.40 ± 0.39	3.96 ± 0.50**
Uric acid (mmol/L)	0.06 ± 0.01	0.06 ± 0.01	0.07 ± 0.01	0.07 ± 0.01
Sodium (mmol/L)	142.40 ± 0.89	143.60 ± 1.14	144.80 ± 1.10	144.00 ± 2.55
Potassium (mmol/L)	4.04 ± 0.70	3.84 ± 0.30	4.90 ± 0.37**	5.98 ± 0.59**
Chloride (mmol/L)	104.00 ± 1.41	106.60 ± 1.82	105.80 ± 0.45	105.40 ± 1.67
Total cholesterol (mmol/L)	2.16 ± 0.29	2.02 ± 0.27	1.62 ± 0.47	1.90 ± 0.37
Total protein (G/L)	56.00 ± 2.92	55.00 ± 1.87	58.60 ± 2.61	61.40 ± 4.83
Albumin (G/L)	35.60 ± 1.82	34.80 ± 1.48	37.40 ± 1.34	39.80 ± 3.70
Globulin (G/L)	20.40 ± 1.14	20.20 ± 0.84	21.20 ± 1.79	21.60 ± 1.34
Total bilirubin (μmol/L)	1.60 ± 0.55	2.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00
Alkaline phosphatase (IU/L)	131.20 ± 20.17	155.00 ± 40.74	144.80 ± 28.49	115.40 ± 22.78
SGOT (AST) (IU/L)	212.20 ± 19.20	188.60 ± 21.95	242.20 ± 23.88	295.00 ± 28.06**
SGPT (ALT) (IU/L)	55.80 ± 6.30	54.20 ± 8.79	56.40 ± 3.97	61.00 ± 2.83
GGT (IU/L)	2.00 ± 0.71	0.40 ± 0.55	1.40 ± 2.61	1.60 ± 1.14

Values are expressed in mean ± SD (n = 5/group).

^**Significant difference with control (ANOVA, Dunnett's t (two-sided) test, p < 0.05).