Table 2.
Mean area of wound (mm2) and % wound contraction during excision wound model.
| Days | Day 0 (before treatment) | 3 | 6 | 9 | 12 | 15 | 17 |
|---|---|---|---|---|---|---|---|
| Group 1 (ethyl acetate) | 229 ± 1.47 (0.00) | 169.5 ± 2.10∗ (25.98) | 90.25 ± 1.70∗ (60.58) | 61.50 ± 1.84∗ (73.14) | 19.50 ± 0.95∗∗ (91.48) | 0.00 ± 0.00 (100) | 0.00 ± 0.00 (100) |
| Group 2 (n-butanol) | 231.25 ± 3.30 (0.00) | 147 ± 1.22∗∗ (36.43) | 117.5 ± 1.04 (49.18) | 48 ± 1.22∗∗ (79.24) | 21 ± 2.41∗∗∗ (90.91) | 0.00 ± 0.00 (100) | 0.00 ± 0.00 (100) |
| Group 3 (aqueous) | 233.5 ± 5.89 (0.00) | 171.5 ± 4.25∗ (26.55) | 118 ± 3.36 (49.46) | 109.5 ± 2.21∗∗ (53.10) | 74.25 ± 1.93 (68.20) | 28.50 ± 3.27∗∗∗ (87.79) | 0.00 ± 0.00 (100) |
| Group 4 (cream) | 228.25 ± 4.23 (0.00) | 196 ± 2.94 (14.12) | 140.75 ± 3.06∗∗ (38.33) | 88 ± 1.22 (61.44) | 59.5 ± 1.65∗∗ (73.93) | 28.25 ± 1.18∗∗ (87.62) | 0.00 ± 0.00 (100) |
| Group 5 (control) | 229.25 ± 2.45 (0.00) | 203.25 ± 2.49 (11.43) | 118 ± 3.13 (48.52) | 93.75 ± 3.75 (59.10) | 84.5 ± 3.5 (63.14) | 54 ± 4.08 (76.44) | 30.5 ± 3.86 (86.69) |
| Group 6 (standard) | 231.29 ± 4.73 (0.00) | 148.25 ± 1.93∗∗ (35.89) | 89.25 ± 2.28∗ (61.40) | 44.25 ± 2.28∗ (80.86) | 18.5 ± 2.72∗∗ (92) | 0.00 ± 0.00 (100) | 0.00 ± 0.00 (100) |
Values are mean ± SEM (percent) of 4 rats in each group. ∗ P < 0.05, ∗∗ P < 0.001, and ∗∗∗ P < 0.0001 compared to respective day control group (statistical analysis was done by one-way analysis of variance followed by Dunnett's test for multiple comparisons).