Table II.

Phenotype-specific asthma therapeutic targeting

Pathology	Phenotype	Therapeutic Intervention
Non-Eosinophilic	Paucigranulocytic / Neutrophilic	IL-17 antagonists Macrolide antibiotics, methotrexate, phosphodiesterase IV inhibitors
Eosinophilic	Allergen-Exacerbated	Allergen avoidance immunotherapy anti-IgE IL-4 antagonists IL-13 antagonists IL-4/IL-13 dual antagonists
	Idiopathic eosinophilic	Corticosteroids IL-5/IL-5R antagonists
	Aspirin-exacerbated respiratory disease	Leukotriene modifiers Aspirin desensitization