Table 1.
C. trachomatis vaccine candidate antigens and immune responses
| Protein | Molecular Weight1 | Localization within Chlamydia1 | Immunization (adjuvants) | Protection levels | Type of T cell response or source of recognizing T cells | Ref |
|---|---|---|---|---|---|---|
| CT043 | 18.4 | Membrane | DNA/Protein boost (lung infectin model) | 2.6-log bacterial reduction in lungs | Th1 type responses | 76 |
| ArtJ | 28.6 | periplasm/type II transporter | ND | ND | Neutralyzing anibodies in vitro | 77 |
| CrpA | 15 | Inclusion membrane | Vaccinia virus | Partial protection | CD8 T cells expanded | 85 |
| CPAF | 65 | Chlamydial Protease | CPAF plus IL-12 | Significant reduction of bacteria in vagina | Antibodies and IFN-g | 78 |
| Tarp | 119 | Type III secretion system protein | CpG and IFA | Significant reduction of bacteria in vagina | Th1 type response | 79 |
| PmpG | 107 | Membrane | Peptide or protein pulsed DCs | ∼60% reduction of IFUs in vagina | CD4+T cells or total T cells producing IFN-γ | 75 |
| PmpE | 104 | Membrane | Peptide or protein pulsed DCs | ∼50% reduction of IFUs in vagina | CD4+T cells or total T cells producing IFN-γ | 75 |
| RplF | 19.8 | Ribosome | Peptide or protein pulsed DCs | ∼50% reduction of IFUs in vagina | CD4+T cells or total T cells producing IFN-γ | 75 |
| PmpD | 160 | Membrane | ND | ND | Recognized by human CD4+T cells clones | 84 |
| MOMP | 40 | Membrane | Freund's adjuvant, CpG-containing ODNs, OspA, rVCGs. | Up to 70% reduction of IFUs in vagina | TH1-like with IFN-γ production or TH1/TH2 mix. | 81, 82, 83, 93 |
| NrdB | 42.7 | ND | Cholera toxin + CpG | Partial protection | CD4+ T cells | 74 |
1Molecular weight in kDa. Abbreviations: MOMP, outer membrane protein; rVCGs, recombinant Vibrio cholerae ghost; OspA, outer surface protein A of Borrelia burgdorferi; IFUs, inclusion forming units; ReA, reactive arthritis; Cap1, class I accessible protein 1; CrpA, cysteine-rich protein A; PmpD, PmpG, PmpE, polymorphic membrane protein D, G, or E; RplF, ribosomal protein L6; NrdB, ribonucleoside reductase, small chain protein; CPAF, chlamydial protease-like activity factor; Tarp, type III-secreted effector protein; CrpA, cystein rich protein A; IFA, incomplete Freund's adjuvant; ArtJ, arginine binding protein J; ND, not determined.