Table 3. Major signaling cascades identified with significant difference in expression and hence signaling propensity*,+.
| Cascade | MEF vs. RPL (Log2FC) | Average | |||||
|---|---|---|---|---|---|---|---|
| BMP | BMP2→ | BMPR2→ | SMAD4→ | ID1→ | Mesoderm Induction | ||
| +(1.75) | +(1.05) | +(0.49) | +(1.18) | 1.12 | |||
| NODAL | NODAL→ | SMAD4→ | EP300→ | FOXC1 → | Mesoderm Induction | ||
| +(0.31) | +(0.49) | +(0.61) | +(2.54) | 0.99 | |||
| WNT | WNT3→ | FZD3→ | FRAT2→ | AXIN2→ | LEF1→ | FOXC1+ | |
| +(0.62) | +(0.94) | +(0.57) | +(0.41) | +(1.08) | +(2.54) | 1.03 | |
| FGF | FGF2→ | FGFR3→ | RRAS→ | FOXC1→ | Mesoderm Induction | ||
| +(0.81) | +(2.03) | +(−0.46) | +(2.54) | 1.23 | |||
| Hedgehog | ZIC2→ | GLI2→ | FOXC1→ | Mesoderm Induction | |||
| +(0.99) | +(0.65) | +(2.54) | 1.39 | ||||
*Log2 Fold Change is multiplied by +1 for substrate activation ‘→’, and −1 for inhibition ‘−’ in evaluating signaling propensity. +Mesoderm Induction follows.