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. 2016 Aug 9;6:31198. doi: 10.1038/srep31198

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) RDH3 and PDH3 partly inhibit apoptosis induced by 3-NP treatment in PC12 cells. After TAT fused peptides were pre-incubated for 1 hour, the cells were treated with 3-NP. After 24 h, apoptosis was analyzed as a sub-G1 fraction by FACS (Top; FACS histogram, Bottom; graph of sub-G1 population). Data shown are the means ± SD (n = 3). ^a,bp < 0.05 for 3-NP -treated cells versus 3-NP + PDH3-, or 3-NP + RDH3-treated cells by ANOVA. (B) RDH3 and PDH3 partly inhibit apoptosis induced by rotenone treatment in PC12 cells. After TAT fused peptides were pre-incubated for 1 hour, the cells were treated with rotenone. After 24 h, apoptosis was analyzed as a sub-G1 fraction by FACS (Top; FACS histogram, Bottom; graph of sub-G1 population). Data shown are the means ± SD (n = 3). ^a,bp < 0.05 for rotenone-treated cells versus rotenone + PDH3-, or rotenone + RDH3-treated cells by ANOVA.