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. 2016 Aug 9;6:30951. doi: 10.1038/srep30951

Figure 1. Effects of baicalin (40, 80 and 160 mg/kg) on different behaviors in the CORT model of anxiety/depression.

Figure 1

A schematic representation of the experimental procedure is shown in (A). Graphs show the effect of baicalin on body weight (B), performance in the open field test (C–E), locomotor activity (F), immobility time in the tail suspension test (G), immobility time in the forced swimming test (H) and performance in the elevated plus maze (I). Baicalin significantly improves several anxiety and depression-like behaviors induced by chronic CORT treatment. Representative images of movement tracks in the open field test are shown in (C). Data are expressed as means ± S.E.M (n = 12–15 mice/group). *P < 0.05, **P < 0.01 and ***P < 0.001 vs vehicle. #P < 0.05, ##P < 0.01 and ###P < 0.001 vs CORT model.