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. 2016 Aug 9;6:30951. doi: 10.1038/srep30951

Figure 4. Effects of baicalin (40, 80 and 160 mg/kg) on the levels of FKBP5, SGK1 and phosphorylated SGK1 in the CORT model of anxiety/depression.

Figure 4

Representative western blots of protein expression are shown (A). The graphs show quantification of FKBP5 protein level (B), SGK1 protein level (C), SGK1 phosphorylation at S422 (D) and SGK1phosphorylation at T256 (E). Baicalin significantly decreases the level of FKBP5, pSer422/SGK1 and pThr256/SGK1 in the CORT model of anxiety/depression. All gels were run under the same experimental conditions and were cropped based on the molecular weight of the target protein (full-length blots are presented in Supplementary Figs S10–S13). The boundary between the gels is delineated by a black line. Data are expressed as means ± S.E.M (n = 6–8 mice/group). *P < 0.05 and **P < 0.01 vs vehicle. #P < 0.05, ##P < 0.01 and ###P < 0.001 vs CORT model.