Table 2. SNPs of EGFR and SYNE2 genes are associated with p21 expression in HBV-related HCC.

SNP	Chr	Position	Gene	Allele	Negative group	Positive group	MAF	P value*
rs2227983	7	55229255	Nonsynonymous: EGFR	G/A	71/135/89	42/52/12	0.49	3.61 × 10−5
rs6950826	7	55223176	Intron: EGFR	G/A	158/103/34	34/55/15	0.32	4.06 × 10−3
rs8010699	14	64522843	Nonsynonymous: SYNE2	A/G	9/77/204	10/38/55	0.19	2.41 × 10−4
rs3829767	14	64519455	Nonsynonymous: SYNE2	A/G	9/80/201	10/38/53	0.20	2.94 × 10−4
rs4027402	14	64496749	Nonsynonymous: SYNE2	C/T	12/85/189	15/34/51	0.22	3.60 × 10−4
rs9944035	14	64447776	Nonsynonymous: SYNE2	T/C	198/86/8	56/41/9	0.10	5.46 × 10−4
rs4902264	14	64491695	Nonsynonymous: SYNE2	T/C	7/82/202	9/37/55	0.19	8.03 × 10−4
rs4027405	14	64498037	Nonsynonymous: SYNE2	G/A	4/72/215	8/30/61	0.16	1.72 × 10−3
rs1890908	14	64519035	Nonsynonymous: SYNE2	A/G	3/64/227	6/29/68	0.14	3.63 × 10−3

^*Adjustment for age, gender, smoking status, drinking status, BMI, BCLC stage, TP53 expression status, TACE status before hepatectomy, pathological grade and hepatic cirrhosis.

SNP = Single nucleotide polymorphism, OR = odds ratio, 95% CI = 95% confidence intervals. Chr = chromosome; MAF = minor allele frequency.