Table 3. Genetic model of rs2227983, rs6950826, rs8010699, rs4027405 and rs1890908.
| SNPs | Group |
OR* (95% CI) | P value* | |
|---|---|---|---|---|
| Negative | Positive | |||
| rs2227983 Additive | ||||
| AA | 89 | 12 | Ref. | 3.73 × 10−5 |
| AG | 135 | 52 | 3.23 (1.58–6.58) | 1.26 × 10−3 |
| GG | 71 | 42 | 5.65 (2.66–12.00) | 6.44 × 10−6 |
| rs6950826 Overdominant | ||||
| AA/GG | 192 | 49 | Ref. | |
| AG | 103 | 55 | 2.08 (1.25–3.45) | 4.64 × 10−3 |
| rs8010699 Additive | 129 | 51 | ||
| GG | 204 | 55 | Ref. | 2.29 × 10−3 |
| GA | 77 | 38 | 1.83 (1.12–2.99) | 0.0155 |
| AA | 9 | 10 | 4.12 (1.60–10.64) | 3.43 × 10−3 |
| rs4027405 Dominant | ||||
| AA | 215 | 61 | Ref. | |
| AG/GG | 76 | 38 | 1.84 (1.11–3.04) | 0.0177 |
| rs1890908 Dominant | ||||
| GG | 227 | 68 | Ref. | |
| GA/AA | 67 | 35 | 2.00 (1.20–3.33) | 7.79 × 10−3 |
SNP = single nucleotide polymorphism, OR = odds ratio, 95% CI = 95% confidence intervals. Chr = chromosome; MAF = minor allele frequency, Ref. =reference.
*Adjustment for age, gender, smoking status, drinking status, BMI, BCLC stage, TP53 expression status, TACE status before hepatectomy, pathological grade and cirrhosis.