Table 4. Associations of haplotypes of EGFR (rs6950826, rs2227983) and SYNE2 (rs4027405, rs1890908 and rs8010699) SNPs with p21 expression.
Haplotypes | Positive (2n) | Negative (2n) | OR (95% CI) | P value |
---|---|---|---|---|
EGFR | ||||
G-A | 76 | 308 | Ref. | 1.16 × 10−4 |
A-G | 88 | 164 | 0.46 (0.32–0.86) | 2.43 × 10−5 |
Othersa | 50 | 125 | 0.62 (0.41–0.93) | 0.0219 |
SYNE2 | ||||
A-G-G | 153 | 486 | Ref. | 3.53 × 10−3 |
G-A-A | 45 | 71 | 0.49 (0.33–0.75) | 8.63 × 10−4 |
Othersb | 16 | 39 | 0.76 (0.41–1.40) | 0.383 |
OR = odds ratio, 95% CI = 95% confidence interval, Ref. =reference.
aOthers include haplotypes G-G and A-A.
bOthers include haplotypes A-G-A and G-G-G.