Table 5. Survival on the basis of genotypes of rs4027405 and rs1890908.
| SNP | Patients | MST (months) | Crude HR (95% CI) | P value | Adjusted HR* (95% CI) | P value* |
|---|---|---|---|---|---|---|
| rs4027405 | ||||||
| AA | 276 | 58 | Ref. | 0.029 | Ref. | 0.003 |
| AG | 102 | 39 | 1.48 (1.08–2.04) | 0.016 | 1.81 (1.22–2.67) | 0.003 |
| GG | 12 | 27 | 1.72 (0.84–3.53) | 0.141 | 2.40 (1.05–5.50) | 0.039 |
| AG+GG | 114 | 38 | 1.51 (1.11–2.05) | 0.009 | 1.86 (1.28–2.69) | 0.001 |
| Missing | 15 | |||||
| rs1890908 | ||||||
| GG | 295 | 52 | Ref. | 0.013 | Ref. | 0.006 |
| GA | 93 | 39 | 2.10 (0.93–4.78) | 0.076 | 2.04 (0.84–4.92) | 0.115 |
| AA | 9 | 27 | 1.52 (1.10–2.11) | 0.011 | 1.81 (1.22–2.70) | 0.003 |
| GA+AA | 102 | 38 | 1.57 (1.15–2.14) | 0.005 | 1.84 (1.26–2.68) | 0.002 |
| Missing | 8 | |||||
HR = hazard ratio, 95% CI = 95% confidence interval, MST = median survival time, Ref. =reference.
*Adjustment for age, gender, BMI, race, smoking status, drinking status, child-pugh class, cirrhosis, BCLC stage, pathological grade, TACE status post hepatectomy, antiviral therapy after hepatectomy, radical resection, intrahepatic metastasis, vascular invasion and PVTT.