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. 2016 Aug 9;6:31315. doi: 10.1038/srep31315

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Copyright © 2016, The Author(s)

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(A) Significant inhibition of cell colony formation was observed upon treatment with CMSP (20 μg/ml) for 10 days. The number of colonies was calculated and plotted on the histogram (n = 3). **P < 0.01, compared with the control group. (B) Effect of CMSP on the migration and invasion ability following exposure to different concentrations (10, 20 or 40 μg/ml) for 24 h was investigated by the transwell assay. The number of migrated and invaded cells was calculated (n = 3). **P < 0.01, compared with the control group. (C) Effect of CMSP on the mobility ability of Kyse30 and TE-13 cells after exposure for 48 h was investigated by the wound healing assay. The wounds were photographed, and the wound closure percentage from a representative experiment (n = 3) was temporally measured using Axio Vison software. **P < 0.01, compared with the control group. (D) The protein levels of the EMT-related proteins MMP2, E-cadherin N-cadherin, and vimentin, as measured by western blotting. β-Actin served as a loading control. The data presented are means ± SD from at least three independent experiments. *P < 0.05, **P < 0.01, compared with the control group.