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. 2016 Aug 9;6:31315. doi: 10.1038/srep31315

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) CMSP treatment inhibited tumour growth of Kyse30 cells in vivo. Left: Representative images of tumours formed in nude mice. Right: Tumour growth curves of xenograft tumours and measurement of the tumour weight (n = 6 for each group). (B) Histological analysis of the tumour tissues of mice in all of the groups. Representative H&E images are shown (×400). (C) Representative immunohistochemical images showing the expression levels of C-myc and N-myc in the tumour tissues of both groups (×400). (D) The content of CEA, SCC, IL-6 and MIC-1 in the serum of nude mice treated with CMSP was assayed by ELISA. The data presented are means ± SD from at least three independent experiments. **P < 0.01, compared with the control group. (E) Histological analysis of sections from the spleen and livers of mice treated with CMSP or untreated mice. Representative H&E images are shown (×400).