Figure 1. Cur in combination with red united blue light irradiation effectively induces cell death in A375 cells.

(A) A375 cells were pre-processed with Cur (0–5 μM) for 2 h, and then irradiated with red light, blue light and combined utilization of red and blue light, or protected from light respectively. Twenty hours after the last treatment, cell viability was detected by CCK-8 assay kit. The inhibition ration is in a dosage-dependant pattern. (B) A375 cells were treated as described above, and then stained with bisbenzimide. (i) Nuclear changes in A375 cells treated with Cur and light irradiation; (ii) The assessment was carried out by calculating about 200 cells of each probe of light protected or irradiated cells. Bars between control groups and treated groups are remarkable different at p < 0.05(*) or p < 0.01(**) level.