. 2016 Aug 9;16:392. doi: 10.1186/s12879-016-1711-z

Table 2.

Time to adequate antibiotic therapy and risk ratios for in-hospital mortality and unfavourable outcome at discharge among patients with community-acquired bacterial meningitis

Adequate antibiotic therapy initiated	Risk ratio for in-hospital mortality (95 % CI)		Risk ratio for unfavourable outcome (95 % CI)
Adequate antibiotic therapy initiated	Crude	Adjusted^a	Crude	Adjusted^b
0–2 h after admission	Ref.	Ref.	Ref.	Ref.
2–4 h after admission	1.1 (0.5–2.8)	1.2 (0.5–2.7)	1.4 (0.9–2.2)	1.5 (0.9–2.2)
4–6 h after admission	1.4 (0.4–5.3)	1.4 (0.5–3.6)	1.1 (0.5–2.6)	1.1 (0.6–2.2)
>6 h after admission	2.1 (1.0–4.2)*	1.6 (0.8–3.2)	1.7 (1.2–2.5)*	1.5 (1.0–2.2)*

*p < 0.05. CI indicates confidence interval. ^aAdjusted for age >65 years, Glasgow Coma Score <13 and arterial systolic hypotension (<90 mmHg) at admission. ^bAdjusted for age >65 years, Glasgow Coma Score <13, arterial systolic hypotension (<90 mmHg), bacterial aetiology (S. pneumoniae yes/no) and adjunctive dexamethasone treatment (yes/no)