Table 1.

Timeline

1993:	Preterm birth (35th week of pregnancy); bronchopulmonary dysplasia; severe obstructive pulmonary disease
1994:	Echocardiography: enlarged RV and RA; normal LV and LA; small PDA with left-to-right shunt
2006:	Aortic angiography: PDA diameter, 3.5 mm
	Right heart catheterization and PDA trial occlusion: mPAP, 70 mmHg; RV pressures did not significantly decrease after trial occlusion
	Echocardiography: RV/LV/PV diameter, 24/55/34 mm; maximal pressure gradient across PDA, 16 mmHg
2006 – 2014:	Bosentan therapy and close meshed therapy monitoring
2008:	Echocardiography: RV/LV/PV diameter, 28/54/35 mm; maximal pressure gradient across PDA, 16 mmHg
	Right heart catheterization and PDA trial occlusion: PAP, 94/53/70 mmHg; RAP, 4 mmHg. RV pressures did not significantly decrease after trial occlusion
2013:	Echocardiography: RV/LV/PV diameter, 24/59/39 mm
2014:	Right heart catheterization: see case presentation. Clinical classification: PAH associated with congenital heart disease (PDA) according to positive treatment effect of Bosentan
	Cardiac MR: see case presentation
since 2014:	Macitentan therapy

PDA, patent ductus arteriosus, RV right ventricle, LV left ventricle, PV pulmonary valve, RVP systolic/diastolic/mean, right ventricular pressure, PAP systolic/diastolic/mean, pulmonary arterial pressure, RAP right atrial pressure, PAH pulmonary arterial hypertension