Table 1.
Differential Diagnosis of UC and CD
| Characteristic | UC | CD |
|---|---|---|
| Rectal involvement | Almost always | Frequent |
| Small bowel involvement | Rare | Frequent |
| Continuous lesions | Always | Infrequent |
| Depth of ulceration | Mucosa | Deeper than mucosa |
| Cobblestone appearance | No | Yes |
| Stricture | Rare | Frequent |
| Fistula | No | Frequent |
| Perianal lesions | No | Frequent |
| pANCA | ++ | + |
| ASCA | + | ++ |
UC, ulcerative colitis; CD, Crohn’s disease; pANCA, perinuclear antineutrophil cytoplasmic antibodies; ASCA, anti-Saccharomyces cerevisiae antibodies.