Table 1.
All | CASP8 -652 6N InsDel genotype | P-value | |||
---|---|---|---|---|---|
InsIns | InsDel | DelDel | |||
n (%) | 200 | 42 (21.0) | 101 (50.5) | 57 (28.5) | |
Age at diagnosis (years ± SD) | 56.46 ± 12.1 | 55.00 ± 10.4 | 57.19 ± 12.4 | 56.26 ± 12.6 | 0.676 |
Tumor type | |||||
Ductal | 136 (68.0) | 28 (20.6) | 68 (50.0) | 40 (29.4) | 0.243 |
Lobular | 43 (21.5) | 12 (27.9) | 23 (53.5) | 8 (18.6) | |
Others | 21 (10.5) | 2 (9.5) | 10 (47.6) | 9 (42.9) | |
Tumor size (mm ± SD) | 24.20 ± 16.8 | 23.51 ± 19.2 | 25.11 ± 17.1 | 23.07 ± 14.5 | 0.837 |
Tumor stage | |||||
pT1 | 107 (53.5) | 24 (22.4) | 53 (49.5) | 30 (28.1) | 0.540 |
pT2 | 71 (35.3) | 11 (15.5) | 39 (54.9) | 21 (29.6) | |
pT3+4 | 22 (11.0) | 7 (31.8) | 9 (40.9) | 6 (27.3) | |
Lymph node status | |||||
pN0 | 115 (57.5) | 24 (20.9) | 61 (53.0) | 30 (26.1) | 0.592 |
pN+ | 85 (42.5) | 18 (21.2) | 40 (47.1) | 27 (31.8) | |
UICC stage | |||||
I | 76 (38.0) | 17 (22.4) | 37 (48.7) | 22 (28.9) | 0.442 |
II | 78 (39.0) | 13 (16.7) | 46 (59.0) | 19 (24.4) | |
III + IV | 46 (23.0) | 12 (26.0) | 18 (39.1) | 11 (23.9) | |
Grade | |||||
1 | 71 (37.4) | 16 (22.5) | 35 (49.3) | 20 (28.2) | 0.379 |
2 | 68 (35.8) | 10 (14.7) | 40 (58.8) | 18 (26.5) | |
3 | 51 (26.8) | 13 (25.5) | 21 (41.2) | 17 (33.3) | |
Estrogen receptor status | |||||
negative | 53 (32.5) | 12 (7.4) | 29 (17.8) | 12 (7.4) | |
positive | 110 (67.5) | 25 (15.3) | 50 (30.7) | 35 (21.5) | 0.432 |
Her2 status | |||||
negative | 138 (83.6) | 30 (18.1) | 68 (41.2) | 40 (24.2) | 0.835 |
positive | 27 (16.4) | 5 (3.0) | 15 (9.1) | 7 (4.2) | |
Treatment | |||||
Surgical treatment | |||||
breast conserving | 50 (25.0) | 10 (20.0) | 23 (46.0) | 17 (34.0) | 0.604 |
ablative | 150 (75.0) | 32 (21.3) | 78 (52.0) | 40 (26.7) | |
Adjuvant therapy | |||||
no adjuvant therapy | 112 (56.0) | 22 (19.6) | 62 (57.1) | 28 (25.0) | 0.285 |
Tam and/or CMF | 88 (44.0) | 20 (22.7) | 39 (44.3) | 29 (33.0) |
Tam Tamoxifen, CMF cyclophosphamide, methotrexate and 5 fluorouracil. Data are numbers with percentages given in brackets. Categorical variables were analyzed by χ2 statistics. P values were calculated using ANOVA for continuous variables