Fig. 2.

The effects of olanzapine and haloperidol on MK-801-induced memory impairment in the Morris water maze test. Escape latency (A), escape distance (B), and speed (C) were determined over 9 days (4 trials/day) after training. MK-801 (0.1 mg/kg) was administered 20 minutes prior to behavioral testing over 9 days. Following 6 days of treatment with MK-801, either olanzapine (0.05 mg/kg) or haloperidol (0.05 mg/kg) was administered 40 minutes prior to treatment with MK-801 for a total of 4 days. The black box represents the period of treatment with haloperidol or olanzapine. All values are mean±standard error of mean for five animals per group. *p<0.05 vs. control group, ^†p<0.05 vs. MK-801-treated group.