Table 1.
Baseline Demographic Characteristics, Comorbidities, and CRS-Related Measures in Patients With and Without Depressiona
| Variable | Total | No Depression (PHQ2 Score <3; Range, 0–6) |
Depression (PHQ2 Score ≥3; Range, 0–6) |
P Value |
|---|---|---|---|---|
| Total No. of patients | 685 | 518 | 167 | … |
| Demographic | ||||
| Age, mean (SD), y | 50.5 (15.0) | 50.8 (15.3) | 49.7 (14.4) | .38 |
| Male sex | 332 (48.4) | 260 (50.1) | 72 (43.1) | .12 |
| White race | 582 (85.0) | 440 (84.9) | 142 (85.0) | .72 |
| Smoking status, mean (SD), packs per day |
0.03 (0.17) | 0.03 (0.16) | 0.05 (0.19) | .20 |
| Alcohol consumption, mean (SD), g/wk |
25.0 (52.4) | 28.5 (56.5) | 14.1 (34.5) | .002 |
| Comorbidities | ||||
| Asthma | 255 (37.2) | 186 (35.8) | 69 (41.3) | .20 |
| AERD | 57 (8.3) | 41 (7.9) | 16 (9.6) | .49 |
| COPD | 31 (4.5) | 20 (3.9) | 11 (6.6) | .14 |
| Physician-diagnosed depression |
94 (13.7) | 47 (9.1) | 47 (28.1) | <.001 |
| Fibromyalgia | 24 (3.5) | 17 (3.3) | 7 (4.2) | .58 |
| CRS-related metrics | ||||
| CRS with polyps | 254 (37.1) | 194 (37.4) | 60 (35.9) | .74 |
| AFRS | 19 (2.8) | 14 (2.7) | 5 (3.0) | .84 |
| Allergy | 171 (24.9) | 130 (25.1) | 41 (24.6) | .90 |
| Revision surgery | 287 (41.8) | 197 (38.0) | 90 (53.9) | <.001 |
| Endoscopy score, mean (SD)b | 6.0 (3.9) | 5.9 (3.9) | 6.3 (3.7) | .23 |
| Total No. of patients who underwent endoscopy |
683 | 516 | 167 | … |
| CT score, mean (SD) (range, 0–24) |
11.8 (6.3) | 11.7 (6.35) | 12.2 (6.16) | .40 |
| Total No. of patients who underwent CT |
661 | 500 | 161 | … |
Abbreviations: AERD, aspirin-exacerbated respiratory disease; AFRS, allergic fungal rhinosinusitis (defined by the Bent-Kuhn criteria); COPD, chronic obstructive pulmonary disease; CRS, chronic rhinosinusitis; CT, computed tomography; PHQ2, 2-item Patient Health Questionnaire. Ellipses indicate data not applicable.
a
Data are presented as number (percentage) of patients unless otherwise indicated.
b
Endoscopy results are based on Lund-Kennedy staging system (score range, 0–20).