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. 2016 Aug 8;17:27. doi: 10.1186/s12865-016-0165-9

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Weight loss is greater in cPLA₂α^−/− than cPLA₂α^+/+ mice during C. albicans lung infection. Body weight of cPLA₂α^−/− (KO, open symbols) and cPLA₂α^+/+ (WT, closed symbols) mice was monitored after intratracheal instillation of saline (squares) or C. albicans (CA, circles) using an inoculum of (a) 10⁷ or (b) 10⁶ CA. Body weight is expressed as the % of the weight determined just prior to instillation of C. albicans or saline (n = 8–13 mice/group, from 4–6 independent experiments). *P < 0.05 compared to cPLA₂α^+/+ with saline; #P < 0.05 compared to cPLA₂α^−/− with saline; **P < 0.05 compared to cPLA₂α^+/+ with CA. c Survival of female cPLA₂α^−/− (KO, open symbols) and cPLA₂α^+/+ (WT, closed symbols) mice was monitored after intratracheal administration of 5 x 10⁶ CFU C. albicans (6 mice/group)