Fig. 5.

Pro-inflammatory cytokines and chemokines are higher in BALF from cPLA₂α^−/− than cPLA₂α^+/+ mice during C. albicans infection. cPLA₂α^−/− (KO) and cPLA₂α^+/+ (WT) mice were challenged with saline or 10⁶ C. albicans (CA) for 6, 12 and 24 h. The levels of (a) IL1α, (b) IL1β, (c) TNFα, (d) IL6, (e) CSF2, (f) CCL20, (g) CXCL1 and (h) CSF3 were determined by ELISA (n = 6–10 mice/group in 3–5 experiments). *P < 0.05 compared to cPLA₂α^+/+ saline control; ^# P < 0.05 compared to cPLA₂α^−/− saline control; **P < 0.05 compared to cPLA₂α^+/+ with CA