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. Author manuscript; available in PMC: 2016 Oct 21.
Published in final edited form as: Nature. 2016 Mar 30;532(7599):329–333. doi: 10.1038/nature17640

Figure 5. N6-mA upregulation induced transcriptional silencing on the X chromosome, which is persistent during differentiation.

Figure 5

a, Aggregation of 5mC. b, Aggregation of H3K9Me3 signals. c, Normalized frequency of decommissioned enhancers was plotted as a function of their genomic distance to full-length L1 elements red, N6-mA enriched, median: 484 kb; grey, non-enriched, median: 2 Mb. d, RT-qPCR analysis of the Gm8817 and Rhox6 genes (on the X chromosome) during embryoid body differentiation. *P < 0.05, t-test; error bars, ± s.e.m. of three biological replicates. e, Schematics of Alkbh1 and N6-mA functions (see main text).