Table 2.
Main grade 3–4 toxicities of the included RCTs
| References | Kwon et al. [14] | Kim et al. [15] | Zhu et al. [16] | ARTIST 2012/2015 | ||||
|---|---|---|---|---|---|---|---|---|
| Characteristics | CRT | CT | CRT | CT | CRT | CT | CRT | CT |
| Patient number | 31 | 30 | 46 | 44 | 186 | 165 | 230 | 228 |
| Nausea/vomiting | 2 (6.5) | 4 (13.3) | NR | NR | 8 (4.3) | 0 | 35 (15.4) | 36 (15.9) |
| Diarrhea | 1 (3.2) | 0 | NR | NR | 3 (1.6) | 0 | 2 (0.9) | 5 (2.2) |
| Neutropenia | 15 (48.4) | 5 (16.7) | NR | NR | 14 (7.5) | 12 (7.3) | 110 (48.4) | 92 (40.7) |
| Anemia | 4 (12.9) | 5 (16.7) | NR | NR | 0 | 0 | 1 (0.4) | 4 (1.7) |
| Thrombocytopenia | NR | NR | NR | NR | 0 | 0 | 2 (0.9) | 0 |
| Criteria | NR | NR | CTCEA 3.0 | CTCEA 2.0 | ||||
Numbers in the brackets refer to percentages
CRT chemoradiotherapy, CT chemotherapy, NR not reported