Table 1.
Deregulated pathways in HNF-1β mutant cells
| Pathways | Count | P Value | FDR |
|---|---|---|---|
| Metabolic pathways | 125 | <0.001 | 7.59E-37 |
| Pathways in cancer | 57 | <0.001 | 1.38E-27 |
| Wnt signaling | 31 | <0.001 | 9.79E-17 |
| Endocytosis | 35 | <0.001 | 1.20E-15 |
| Exon guidance | 27 | <0.001 | 4.98E-15 |
| Focal adhesion | 30 | <0.001 | 7.40E-13 |
| Basal cell carcinoma | 16 | <0.001 | 1.76E-11 |
| Adherens junction | 18 | <0.001 | 2.19E-11 |
| Melanogenesis | 20 | <0.001 | 4.22E-11 |
| Phosphatidylinositol signaling | 16 | <0.001 | 3.65E-09 |
| Glycerophospholipid metabolism | 16 | <0.001 | 4.98E-09 |
| Hedgehog signaling | 13 | <0.001 | 1.60E-08 |
| Leukocyte endothelial migration | 18 | <0.001 | 4.01E-08 |
| MAPK signaling | 27 | <0.001 | 4.90E-08 |
The analysis was performed on direct HNF-1β targets with P<0.05. Columns indicate KEGG pathway, gene count, P value, and FDR for the enrichment. FDR, false discovery rate; MAPK, mitogen-activated protein kinase, KEGG, Kyoto Encyclopedia of Genes and Genomes.