Table 3.
Association between mitochondrial DNA copy number and incident CKD
| Modela | n | Q1 | Q2 HR (95% CI) | Q3 HR (95% CI) | Q4 HR (95% CI) | P for trend |
|---|---|---|---|---|---|---|
| Model 1 | ||||||
| Whites | 7191 | 1.00 | 0.78 (0.66, 0.92) | 0.75 (0.63, 0.88) | 0.68 (0.58, 0.81) | <0.001 |
| Blacks | 1867 | 1.00 | 0.89 (0.69, 1.16) | 0.87 (0.67, 1.13) | 0.58 (0.44, 0.78) | <0.001 |
| Combined | 9058 | 1.00 | 0.81 (0.71, 0.93) | 0.78 (0.68, 0.9) | 0.65 (0.56, 0.75) | <0.001 |
| Model 2 | 9058 | 1.00 | 0.86 (0.75, 0.98) | 0.88 (0.76, 1.01) | 0.76 (0.66, 0.89) | <0.001 |
| Model 3 | 9058 | 1.00 | 0.89 (0.77, 1.02) | 0.95 (0.82, 1.09) | 0.80 (0.69, 0.92) | 0.001 |
| Model 4 | 8135 | 1.00 | 0.83 (0.72, 0.96) | 0.92 (0.79, 1.07) | 0.75 (0.64, 0.87) | <0.001 |
| Sensitivity analysis | ||||||
| Model 4 with time varying covariatesb | 8135 | 1.00 | 0.83 (0.71, 0.96) | 0.92 (0.79, 1.07) | 0.75 (0.64, 0.87) | <0.001 |
| Model 4 excluding WBC count ≥10 × 103/μl | 7874 | 1.00 | 0.83 (0.71, 0.97) | 0.93 (0.80, 1.09) | 0.75 (0.64, 0.88) | <0.001 |
| Model 4 adjusting for platelet count and % of monocytes, lymphocytes, and neutrophils | 4233 | 1.00 | 0.86 (0.68, 1.09) | 0.88 (0.69, 1.12) | 0.72 (0.56, 0.93) | 0.004 |
| Model 4 only including participants without microalbuminuriac at visit four (approximately 6 years after baseline) | 6063 | 1.00 | 0.84 (0.70, 1.01) | 0.87 (0.72, 1.05) | 0.77 (0.64, 0.94) | 0.002 |
a
Model 1 adjusted for age, sex, and study center. The combined model included self-reported race as a covariate. P for interaction between self-reported race and mtDNA copy number: 0.18. Model 2 added log-transformed WBC count. Model 3 added baseline eGFR, prevalent coronary heart disease, diabetes, hypertension, smoking status, and BMI. Model 4 added serum albumin, HbA1c, and log-transformed hsCRP that were available at visit two only.
b
Time-varying covariates: incident diabetes and hypertension.
c
Microalbuminuria was defined as urinary albumin-to-creatinine ratio <30 mg/g.