Table 2.

Use of DAAs with immunosuppressive agents

Immunosuppressant	SOF and LDV	OMV, PTV, r, and DSV	SMV	SOF
Cyclosporin	No changes in levels	↑ Cyclosporin levels (r)	↑ Levels of both cyclosporin and SMV	No changes in levels
Tacrolimus	No changes in levels	↑ Tacrolimus levels (r)	↓ Tacrolimus levels; monitor levels closely	No changes in levels
Sirolimus	No changes in levels	↑ Sirolimus levels (r)	↑ or ↓ Levels of sirolimus	No changes in levels

SOF, sofosbuvir; LDV, ledipasvir; OMV, ombitasvir; PTV, paritaprevir; r, ritonavir; DSV, dasabuvir; SMV, simeprevir.