FIGURE 3.

The influence of the Huaiqihuang (HQH) treatment on the protein expression related to proteinuria. A: The protein levels of podocin and nephrin were decreased by the increased concentration of tunicamycin (TM) in the MPC5 cells; B: The mRNA levels of synaptopodin gene were decreased by the increased concentration of TM; C: Both the integrin-α3 and integrin-β1 levels were increased by a low dose of TM (0.5 µmol/l), while their levels were decreased by a high dose of TM (5 µmol/l); D: The TM treatment decreased the Cullin-5 and Bip protein expression in the MPC5 cells, but their levels were increased by the HQH application, indicating the protective role of HQH in the TM-induced MPC5 cells.