Table 3.
List of serum microRNAs that were found to be significantly correlated with specific or total PCDD/PCDFs. All sample groups were merged and used in analysis and significance was analyzed after controlling for cotinine status as a covariate (q<0.25). Highlighted columns show significant p-values (p < 0.05) after Benjamin-Hochberg false discovery rate correction.
| Tetrachloro | Pentachlorodi | Hexachlorodi | Heptachlorodi | Octachlorodi | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| dibenzo.p.di | benzo.p.dioxi | benzo.p.dioxi | benzo.p.dioxi | benzo.p.dioxi | Total | Total | Total | Total | Total | |
| miRNA | oxins | ns | ns | ns | ns | Dioxins | TCDF | PCDF | HxCDF | HpCDF |
| let-7a-5p | 0.954 | 0.981 | 0.868 | 0.966 | 0.47 | 0.985 | 0.929 | 0.01 | 0.807 | 0.366 |
| let-7b-5p | 2.43E-04 | 0.04 | 0.626 | 0.378 | 0.03 | 0.116 | 0.122 | 0.397 | 0.888 | 0.02 |
| let-7d-5p | 0.954 | 0.604 | 0.56 | 0.44 | 0.562 | 0.985 | 0.772 | 0.04 | 0.725 | 0.564 |
| let-7g-5p | 0.954 | 0.499 | 0.04 | 0.297 | 0.097 | 0.985 | 0.04 | 0.46 | 0.672 | 5.02E-06 |
| let-7i-5p | 0.954 | 0.138 | 0.083 | 0.01 | 0.065 | 0.985 | 0.02 | 0.651 | 0.01 | 1.45E-06 |
| miR-1 | 0.954 | 0.04 | 0.208 | 0.544 | 0.595 | 0.985 | 0.03 | 0.827 | 0.923 | 0.21 |
| miR-103a-3p | 0.954 | 0.901 | 0.457 | 0.03 | 0.02 | 0.996 | 0.743 | 0.04 | 0.168 | 0.351 |
| miR-106a-5p | 0.937 | 0.499 | 0.068 | 0.01 | 0.01 | 0.912 | 0.05 | 0.01 | 0.01 | 0.02 |
| miR-107 | 0.954 | 0.419 | 0.258 | 0.01 | 0.01 | 0.902 | 0.276 | 0.134 | 0.147 | 0.292 |
| miR-127-3p | 0.05 | 0.499 | 0.609 | 0.707 | 0.996 | 0.985 | 0.595 | 0.75 | 0.888 | 0.886 |
| miR-130a-3p | 0.761 | 0.266 | 0.609 | 0.05 | 0.01 | 0.996 | 0.088 | 0.827 | 0.168 | 0.603 |
| miR-130b-3p | 0.768 | 0.445 | 0.388 | 0.467 | 0.114 | 0.902 | 0.04 | 0.863 | 0.8 | 1.62E-03 |
| miR-136-5p | 0.441 | 0.579 | 3.92E-03 | 0.05 | 0.065 | 0.902 | 4.75E-03 | 0.332 | 0.15 | 2.75E-08 |
| miR-140-3p | 0.954 | 0.969 | 0.03 | 8.36E-04 | 1.78E-05 | 0.985 | 0.504 | 0.827 | 2.93E-05 | 1.35E-06 |
| miR-140-5p | 0.993 | 0.01 | 0.379 | 0.414 | 0.1 | 0.942 | 0.171 | 0.837 | 0.696 | 0.263 |
| miR-142-3p | 0.667 | 0.03 | 1.63E-07 | 0.01 | 1.78E-05 | 0.116 | 1.81E-06 | 0.994 | 0.01 | 1.23E-17 |
| miR-142-5p | 0.761 | 0.91 | 0.56 | 0.01 | 0.01 | 0.902 | 0.57 | 0.827 | 0.01 | 0.213 |
| miR-144-3p | 0.01 | 0.475 | 0.03 | 0.054 | 0.173 | 0.74 | 0.01 | 0.187 | 0.301 | 0.01 |
| miR-146a-5p | 0.993 | 0.077 | 0.156 | 0.99 | 0.996 | 0.764 | 0.01 | 0.827 | 0.47 | 0.061 |
| miR-148b-3p | 0.993 | 0.493 | 0.171 | 0.544 | 0.814 | 0.902 | 0.101 | 0.994 | 0.913 | 0.04 |
| miR-150-5p | 0.737 | 0.327 | 0.986 | 0.966 | 0.753 | 0.985 | 0.894 | 0.75 | 0.515 | 0.05 |
| miR-151a-5p | 0.973 | 0.995 | 0.705 | 0.04 | 0.02 | 0.996 | 0.877 | 0.04 | 0.111 | 0.745 |
| miR-15a-5p | 0.803 | 0.772 | 0.083 | 0.445 | 0.04 | 0.785 | 0.401 | 0.46 | 0.8 | 0.01 |
| miR-15b-3p | 0.954 | 0.182 | 0.04 | 0.736 | 0.141 | 0.985 | 0.101 | 0.897 | 0.587 | 0.15 |
| miR-16-5p | 0.993 | 0.888 | 0.12 | 0.05 | 0.02 | 0.985 | 0.249 | 0.827 | 0.01 | 1.62E-03 |
| miR-191-5p | 0.993 | 0.729 | 0.129 | 5.22E-04 | 1.78E-05 | 0.902 | 0.158 | 0.376 | 0.01 | 0.02 |
| miR-195-5p | 0.704 | 0.888 | 0.083 | 0.03 | 0.74 | 0.902 | 0.805 | 0.663 | 0.115 | 0.167 |
| miR-199a-5p | 0.993 | 0.73 | 0.02 | 0.237 | 0.223 | 0.985 | 0.088 | 0.801 | 0.137 | 0.01 |
| miR-19b-3p | 0.519 | 0.812 | 0.833 | 0.115 | 0.118 | 0.996 | 0.929 | 0.827 | 0.01 | 0.102 |
| miR-200a-3p | 0.931 | 0.735 | 0.511 | 0.196 | 0.359 | 0.985 | 0.929 | 0.332 | 0.8 | 0.02 |
| miR-2110 | 7.48E-07 | 0.01 | 0.129 | 0.284 | 0.703 | 0.74 | 0.01 | 0.969 | 0.507 | 0.05 |
| miR-215-5p | 0.618 | 0.499 | 0.652 | 0.225 | 0.151 | 0.985 | 0.399 | 0.75 | 0.03 | 0.04 |
| miR-21-5p | 0.799 | 0.604 | 0.199 | 0.246 | 0.052 | 0.902 | 0.57 | 0.603 | 0.338 | 1.62E-03 |
| miR-221-3p | 0.993 | 0.604 | 0.03 | 0.03 | 0.1 | 0.902 | 2.56E-04 | 0.827 | 0.01 | 9.05E-06 |
| miR-22-3p | 0.993 | 0.598 | 0.509 | 0.063 | 0.01 | 0.985 | 0.929 | 0.376 | 0.054 | 0.02 |
| miR-28-5p | 0.448 | 0.604 | 0.509 | 0.063 | 0.28 | 0.764 | 0.651 | 0.463 | 0.07 | 0.04 |
| miR-29b-3p | 0.848 | 0.347 | 0.03 | 0.782 | 0.989 | 0.985 | 0.784 | 0.827 | 0.917 | 0.02 |
| miR-301a-3p | 0.954 | 0.04 | 0.482 | 0.32 | 0.561 | 0.985 | 0.158 | 0.827 | 0.766 | 0.746 |
| miR-30e-5p | 0.954 | 0.59 | 0.379 | 0.03 | 0.01 | 0.985 | 0.236 | 0.46 | 0.064 | 0.02 |
| miR-324-3p | 0.05 | 0.04 | 0.771 | 0.342 | 0.794 | 0.764 | 0.05 | 0.75 | 0.807 | 0.208 |
| miR-32-5p | 0.993 | 0.138 | 2.05E-04 | 4.54E-03 | 0.01 | 0.985 | 3.79E-03 | 0.187 | 0.064 | 9.03E-08 |
| miR-326 | 0.649 | 9.11E-06 | 4.57E-06 | 0.059 | 0.057 | 0.04 | 2.29E-12 | 0.332 | 0.111 | 3.28E-09 |
| miR-328-3p | 0.931 | 0.05 | 1.08E-06 | 0.225 | 0.116 | 0.785 | 4.64E-15 | 0.656 | 0.148 | 1.58E-08 |
| miR-339-3p | 0.803 | 0.566 | 0.414 | 0.115 | 0.03 | 0.985 | 0.14 | 0.292 | 0.426 | 0.547 |
| miR-33a-5p | 0.799 | 0.179 | 2.93E-03 | 0.02 | 0.03 | 0.985 | 1.29E-05 | 0.987 | 0.185 | 1.40E-05 |
| miR-342-3p | 0.448 | 0.731 | 0.136 | 0.115 | 0.359 | 0.985 | 0.714 | 0.292 | 0.05 | 0.619 |
| miR-382-5p | 0.179 | 0.874 | 0.04 | 0.634 | 0.6 | 0.996 | 0.623 | 0.964 | 0.725 | 0.732 |
| miR-409-3p | 0.448 | 0.812 | 0.136 | 0.417 | 0.773 | 0.942 | 0.311 | 0.757 | 0.111 | 4.10E-03 |
| miR-423-3p | 0.954 | 0.04 | 5.79E-06 | 0.428 | 0.385 | 0.785 | 1.05E-06 | 0.994 | 0.538 | 9.03E-08 |
| miR-423-5p | 0.993 | 0.731 | 0.04 | 0.04 | 1.05E-03 | 0.785 | 0.09 | 0.827 | 0.087 | 1.66E-03 |
| miR-484 | 0.803 | 0.106 | 7.26E-04 | 0.03 | 0.01 | 0.58 | 1.31E-07 | 0.292 | 0.04 | 9.03E-08 |
| miR-501-3p | 0.847 | 0.731 | 0.951 | 0.981 | 0.794 | 0.985 | 0.77 | 0.827 | 0.8 | 0.03 |
| miR-584-5p | 0.993 | 0.138 | 0.414 | 0.417 | 0.376 | 0.902 | 0.01 | 0.987 | 0.173 | 0.208 |
| miR-766-3p | 0.847 | 0.604 | 0.89 | 0.04 | 0.223 | 0.902 | 0.684 | 0.105 | 0.504 | 0.54 |
| miR-92b-3p | 0.993 | 0.931 | 0.083 | 0.44 | 0.694 | 0.985 | 0.939 | 0.603 | 0.634 | 0.05 |
| miR-93-5p | 0.332 | 0.731 | 0.457 | 0.01 | 4.28E-03 | 0.985 | 0.734 | 0.063 | 0.148 | 0.02 |