Table 2.

Expression of profibrotic genes in ZL and ZO rats

Gene	Rat group
	ZL‐VE	ZO‐VE	ZO‐FBX	ZO‐FBXlate	ZO‐ENL	ZO‐FBX + ENL
Coll4	0.305±0.037	0.503 ± 0.068a	0.351 ± 0.036	0.425 ± 0.042	0.373 ± 0.025	0.300 ± 0.050b
Fibronectin	0.026 ± 0.003	0.074 ± 0.006a	0.065 ± 0.008a	0.077 ± 0.007a	0.059 ± 0.009a	0.044 ± 0.002a b d
CTGF	0.383 ± 0.034	0.490 ± 0.054	0.389 ± 0.033	0.406 ± 0.044	0.529 ± 0.055	0.192 ± 0.034b e
PAI‐I	0.009 ± 0.002	0.027 ± 0.005a	0.024 ± 0.003a	0.028 ± 0.004a	0.016 ± 0.002b c d	0.008 ± 0.001b c d
FSP1	0.083 ± 0.018	0.185 ± 0.035b	0.104 ± 0.011d	0.137 ± 0.014c	0.122 ± 0.008c	0.095 ± 0.008d
Vimentin	0.239 ± 0.057	0.605 ± 0.094a	0.397 ± 0.054d e	0.783 ± 0.108a	0.632 ± 0.057a	0.376 ± 0.025b d e

mRNA level of a given gene in each sample was normalized to ß‐actin transcript. Explanation of abbreviations is in the text. There were 10 animals in ZL‐VE group and 12 animals in each ZO group.

^a P < 0.05 versus ZL‐VE.

^b P < 0.05 versus ZO‐VE.

^c P < 0.05 versus ZO‐FBX.

^d P < 0.05 versus ZO‐FBXlate; ^ep < 0.05 versus ZO‐ENL.