Fig. 1.

Interactions between lipids and amino acids in native c₈-rings. (A and B) Average radial distribution functions from two independent simulations for lipids in the inner and outer leaflets of the membrane, respectively. Upper and Lower correspond to interactions with cardiolipin and with POPC and POPE, respectively. Their colors correspond to specific amino acids in the bovine c-subunit, as defined in C. (C) Alignment of sequences of c-subunits from cows, S. cerevisiae, and I. tartaricus. Residues interacting with lipids are colored. For the radial distribution curves for the demethylated c₈-rings and c₁₀- and c₁₁-rings from S. cerevisiae and I. tartaricus, respectively, see Figs. S4, S6, and S8.