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IC50 values for inhibition of USP2 by Ub.wt and Ubvs
| Ub substitution | IC50, nM | IC50,K6N/T12H/IC50 |
| WT | 60,000 ± 20,000 | 0.001 |
| K6N | 200 ± 10 | 0.3 |
| T12H | 24,000 ± 1,000 | 0.002 |
| K6N/T12H | 58 ± 7 | 1.0 |
| K6N/T12H/K11T | 56 ± 2 | 1.0 |
| K6N/T12H/Q2D | 22 ± 4 | 2.5 |
| K6N/T12H/N6M | 70 ± 20 | 0.8 |
| K6N/T12H/KllR | 12 ± 5 | 4.7 |
| K6N/T12H/T14L | 21 ± 5 | 2.7 |
| K6N/T12H/E64F | 32 ± 3 | 1.8 |
| K6N/T12H/H68F | 44 ± 7 | 1.3 |
| K6N/T12H/V70N | 52 ± 6 | 1.1 |
| K6N/T12H/R42G | 1,400 ± 200 | 0.04 |
| K6N/T12H/L73W | 2,300 ± 800 | 0.02 |
