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Phosphorylation of PI and PIPs. (A) Schematic depicting the synthesis of the seven phosphoinositides. (B) Chemical structures of PI(4)P, PI(5)P, and PI(3)P. The type I kinase, PIP5K, preferentially phosphorylates PI(4)P at the 5-hydroxyl (red arrow). The type II kinase, PIP4K, preferentially phosphorylates PI(5)P at the 4-hydroxyl. The type III kinase, PIKfyve, preferentially phosphorylates PI(3)P at the 5-hydroxyl.
