Fig. S5.

Sequence homology between ZFP106 and RNA-binding ZnF proteins. (A) A search of the Conserved Domain Database using the amino acid sequence of ZFP106 identified homology to the zinc finger splicing factor PRP11, a homolog of mammalian SF3A2. Protein alignment shows that the region encompasses an N-terminal ZnF of ZFP106 and ZnF of PRP11. (B) The N-terminal ZnFs of ZFP106 share significant homology with the ZnFs of zinc finger RNA-binding protein (ZFR). (C) Alignment of the ZnFs of ZFP106 and other RNA-binding ZnF proteins that contain the conserved C2H2 ZnF motif C-X₂-C-X₁₂-H-X₅-H. Cysteine and histidine residues comprising the C-X₂-C-X₁₂-H-X₅-H motif are highlighted in red. “*” denotes identical, “:” denotes strongly similar and “.” denotes weakly similar residues.