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. 2016 Jul 18;113(31):E4558–E4566. doi: 10.1073/pnas.1608319113

Fig. S2.

Fig. S2.

(A and B) The effect of TRIM33 depletion on JQ1 or GS-626510 sensitivity in a panel of cancer cell lines. (A) The IC50 values for each cell line expressing either shCTRL or shTRIM33 was derived from three independent growth inhibition assays and the mean ± SEM of the fold-change in IC50 (shTRIM33/shCTRL) was calculated (*P < 0.05, paired t test). (B) IC50 values (mean ± SEM) for each cell line. (C) Cell proliferation assay of cell lines expressing two independent shRNAs (B5 and A12) targeting TRIM33. Cells were cultured in 100 nM JQ1, or 50 nM GS-626510 for two weeks and then stained with Crystal violet. (D) Crystal violet quantification measured at 590-nm absorbance corresponding to Fig. 2F.