Table 2.
Patient |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Time | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | Median | p value | |
WML-L | Baseline | 29 | 14 | 7 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0.043 |
Follow-up | 43a | 30a | 36a | 6a | 8a | 0 | 2 | 0 | 0 | 0 | 6 | 0 | 0 | 2 | ||
WML-T | Baseline | 12 | 10 | 5 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 14 | 10 | 0 | 2 | 0.034 |
Follow-up | 14 | 12a | 10a | 4a | 0 | 0 | 4 | 0 | 0 | 0 | 14 | 10 | 0 | 4 | ||
WML-PV | Baseline | 6 | 6 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0.038 |
Follow-up | 8a | 8a | 6a | 0 | 3a | 0 | 0 | 0 | 0 | 0 | 4 | 2a | 0 | 0 | ||
HWMPST | Baseline | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 0.014 |
Follow-up | 3 | 3a | 3a | 2a | 2a | 1 | 1 | 1 | 1 | 1 | 2 | 2a | 2a | 2 | ||
VBR | Baseline | 0.30 | 0.24 | 0.19 | 0.12 | 0.14 | 0.19 | 0.19 | 0.18 | 0.20 | 0.16 | 0.20 | 0.17 | 0.20 | 0.19 | 0.002 |
Follow-up | 0.37a | 0.29a | 0.24a | 0.14 | 0.22a | 0.21 | 0.21 | 0.22a | 0.23 | 0.17 | 0.22 | 0.18 | 0.24a | 0.22 |
Increases more than 20% from baseline. MRI: magnetic resonance imaging; WML: white matter lesion; L: lobar; T: temporal; PV: periventricular; HWMPST: hyperintensity of white matter postero-superior to trigones; VBR: ventricular/brain ratio.