Table 2.

Genotype Distribution and MAF Estimations for the 1905 Birth Cohort and Combined for the 1910 and 1905 Birth Cohorts

			1905 Birth Cohort		1910 and 1905 Birth Cohorts Combined
SNPs	Position*	Variant Location	Major/Minor Allele	MAF	Major/Minor Allele	MAF
rs397703§	33,587,329	Upstream gene variant	A/G	0.21	—	—
rs398655	33,587,652	Upstream gene variant	A/C	0.43	A/C	0.43
		XM_005266617: missense variant H585Q
rs562020	33,592,070	Intron 1 variant	G/A	0.34	G/A	0.32
rs495392	33,592,193	Intron 1 variant	C/A	0.29	C/A	0.28
rs385564	33,592,409	Intron 1 variant	C/G	0.28	—	—
rs575536	33,592,777	Intron 1 variant	G/A	0.27	—	—
rs576404	33,593,100	Intron 1 variant	C/A	0.44	—	—
rs2283368	33,593,270	Intron 1 variant	A/G	0.11	A/G	0.13
rs9526984	33,609,937	Intron 1 variant	A/G	0.09	A/G	0.08
rs1207362§	33,612,839	Intron 1 variant	C/A	0.25	—	—
rs2320762	33,617,174	Intron 1 variant	A/C	0.36	A/C	0.37
rs1888057	33,622,695	Intron 1 variant	G/A	0.20	—	—
rs657049	33,622,817	Intron 1 variant	A/G	0.28	A/G	0.31
rs683907‡	33,624,175	Intron 1 variant	—	—	A/G	0.41
rs687045	33,624,889	Intron 1 variant	A/G	0.44	—	—
rs9536314†	33,627,138	Missense F352V exon 2	A/C	0.15	—	—
rs9527024†	33,627,693	Intron 1 variant	—	—	G/A	0.16
rs9527026	33,628,239	Synonymous variant K385K	G/A	0.16	—	—
rs522796	33,630,055	Intron 3 variant	A/G	0.41	—	—
rs564481	33,634,983	Synonymous variant H589H exon 4	G/A	0.44	—	—
rs648202‡	33,635,463	Synonymous variant A749A exon 4	G/A	0.15	G/A	0.15

Notes: MAF = minor allele frequency; SNP = single-nucleotide polymorphism.

*Genomic position according to genome build GRCh37/hg19 on chromosome 13.

^†Proxy for KL-VS variant.

^‡Proxy for rs564481.

^§Not in Hardy–Weinberg equilibrium.