Table 6.
The Longitudinal Association Study of KL Gene Variants Associated With CCS and MMSE by Random Effect Models at Intercept 93 Years of Age and Yearly Decline (Slope) for Participants in the 1905 Birth Cohort
| SNP | CCS Baseline | CCS Slope | MMSE Baseline | MMSE Slope | ||||
|---|---|---|---|---|---|---|---|---|
| Coefficient (SE) | p Value | Coefficient (SE) | p Value | Coefficient (SE) | p Value | Coefficient (SE) | p Value | |
| rs397703* | 0.10 (0.19) | .60 | −0.11 (0.06) | .07 | 0.47 (0.31) | .14 | −0.17 (0.12) | .14 |
| rs398655* | 0.41 (0.15) | .007 | −0.08 (0.05) | .08 | 0.80 (0.25) | .001 | −0.08 (0.09) | .40 |
| rs562020 | 0.17 (0.16) | .29 | −0.04 (0.05) | .46 | 0.42 (0.26) | .11 | 0.10 (0.10) | .32 |
| rs495392 | 0.14 (0.17) | .41 | −0.08 (0.06) | .13 | 0.54 (0.28) | .05 | −0.07 (0.10) | .48 |
| rs385564 | −0.04 (0.17) | .80 | −0.05 (0.05) | .41 | −0.68 (0.27) | .01 | 0.03 (0.10) | .82 |
| rs575536 | 0.03 (0.17) | .84 | 0.08 (0.05) | .16 | 0.44 (0.28) | .12 | −0.04 (0.10) | .67 |
| rs576404 | −0.06 (0.15) | .70 | 0.01 (0.05) | 0.98 | 0.22 (0.24) | .37 | 0.01 (0.09) | .91 |
| rs2283368 | 0.35 (0.24) | .14 | −0.19 (0.07) | .008 | 0.03 (0.38) | .94 | 0.03 (0.14) | .81 |
| rs9526984 | 0.24 (0.27) | .38 | −0.14 (0.09) | .10 | −0.01 (0.43) | .99 | −0.38 (0.16) | .02 |
| rs1207362 | −0.02 (0.17) | .91 | 0.08 (0.05) | .13 | −0.08 (0.27) | .78 | 0.10 (0.10) | .30 |
| rs2320762 | 0.08 (0.15) | .61 | 0.03 (0.05) | .57 | −0.02 (0.25) | .94 | −0.09 (0.09) | .31 |
| rs1888057 | 0.30 (0.20) | .13 | −0.09 (0.07) | .18 | 0.24 (0.32) | .46 | 0.08 (0.12) | .53 |
| rs657049 | 0.28 (0.17) | .11 | −0.10 (0.06) | .09 | 0.13 (0.28) | .65 | −0.05 (0.10) | .61 |
| rs687045 | −0.22 (0.15) | .15 | 0.03 (0.05) | .52 | −0.11 (0.25) | .65 | 0.08 (0.10) | .39 |
| rs9536314† | −0.01 (0.21) | .99 | −0.11 (0.07) | .10 | −0.62 (0.34) | .07 | −0.12 (0.13) | .33 |
| rs9527026 | −0.03 (0.21) | .90 | −0.10 (0.07) | .13 | −0.51 (0.34) | .13 | −0.15 (0.13) | .23 |
| rs522796 | 0.16 (0.15) | .29 | 0.04 (0.05) | .39 | 0.35 (0.25) | .16 | −0.02 (0.09) | .87 |
| rs564481 | −0.19 (0.15) | .22 | 0.04 (0.05) | .45 | −0.03 (0.25) | .90 | 0.09 (0.09) | .34 |
| rs648202 | 0.41 (0.22) | .06 | −0.05 (0.08) | .48 | 0.73 (0.35) | .04 | 0.04 (0.13) | .79 |
Notes: CCS = cognitive composite score; MMSE = Mini Mental State Examination; SE = standard error; SNP = single-nucleotide polymorphism. Analyses were adjusted for sex and time from intake. Significant results are in italic (p < .05).
*Upstream of the KL gene.
†KL-VS variant.