Table 4.

Relationships Between Regional Lesion Loads and BMI Measured at the Last Visit Prior to MRI, With Covariate Adjustment for the Risk Factors in Table 1 and ICV

Region/Group by BMI	<25 (N = 427)	25–29 (N = 525)	30–34 (N = 298)	35+ (N = 142)	p Value
Total WM	5.1 (0.8)	4.8 (0.7)	4.2 (0.7)	3.8 (0.7)	.02
WM
Frontal	2.3 (0.3)	2.2 (0.3)	1.9 (0.3)	1.9 (0.3)	.16
Temporal	1.2 (0.2)	1.1 (0.2)	0.9 (0.2)	0.9 (0.2)	.05
Parietal	1.4 (0.2)	1.4 (0.2)	1.1 (0.2)	0.9 (0.2)	.01
Occipital	0.4 (0.1)	0.4 (0.1)	0.3 (0.1)	0.3 (0.1)	.04

Notes: BMI = body mass index; ICV = intracranial volume; MRI = magnetic resonance imaging; WM = white matter.