Fig 4. Comparative analysis of T. cruzi parasite Sylvio versus Y strain transcriptome response.

Scatterplot of log₂ fold change in expression of a subset of orthologous T. cruzi parasite genes in Sylvio (x-axis) versus Y strain (y-axis) at 24 hpi versus 4 hpi. Genes that were not significantly differentially expressed are shown as gray dots. Pink dots represent genes that were significantly DE in both strains of parasite but had log₂ FC in one or both strains that was below our cutoff value of 1. Red dots depict genes that were significantly DE and had absolute value of log₂ FC>1 in both strains. The numbers in each quadrant correspond to the total number of significantly DE genes that met the log₂ FC cutoff of 1 (red) or were significantly DE but did not meet the FC cutoff (pink).